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After treatment initiation and dose increases, patients should be observed carefully for signs and symptoms of pancreatitis (including persistent severe abdominal pain, sometimes radiating to the back and which may or may not be accompanied by vomiting)

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It performs many roles, but primarily it acts as your most powerful antioxidant, combating free radicals and oxidative stress that can slow and eventually break down cellular function

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However, in contrast with these findings, Nrf2/ARE downstream genes could be epigenetically suppressed