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The primary pharmacological action is MC4R binding in the brain, which is why erectile function improvements appear within hours while tanning takes weeks

Citation on PubMed Puel A, Doffinger R, Natividad A, Chrabieh M, Barcenas-Morales G, Picard C, Cobat A, Ouachee-Chardin M, Toulon A, Bustamante J, Al-Muhsen S, Al-Owain M, Arkwright PD, Costigan C, McConnell V, Cant AJ, Abinun M, Polak M, Bougneres PF, Kumararatne D, Marodi L, Nahum A, Roifman C, Blanche S, Fischer A, Bodemer C, Abel L, Lilic D, Casanova JL

doi:10.1016/j.jacc.2019.01.065 Young IE, Poobalan A, Steinbeck K, O'Connor HT, Parker HM

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10.1071/an18049 [DOI] [Google Scholar] Srinongkote S., Smriga M., Toride Y

Interference of Antimodified C-Reactive Protein Autoantibodies from Lupus Nephritis in the Biofunctions of Modified C-Reactive Protein