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Very high doses of 5mg (5,000mcg) or more can cause skin issues such as acne or rosacea flare-ups and, in the case of methylcobalamin specifically, anxiety and jitters
In the brain, HGF/c-Met signaling promotes: dendritic spine formation and synaptogenesis
Antioxidant defenses, such as the total amount of GSH, and mitochondrial function were restored both in the liver and kidney [201]
