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Description
Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases
The present review also integrates developments through early 2025, including the discontinuation of the pegtarviliase program and the rebranding of CDX-6512 as SYNT-202, with corresponding updates from clinical trial data, regulatory announcements and pipeline disclosures
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In proteins, irreversible modifications such as carbonylation, nitration and over-oxidation disable enzymes and chaperones, collapsing proteostasis (Korovila et al
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