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Therefore, new antidepressants with different mechanisms are needed to enable clinicians to diversify the treatment options for MDD

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Nature (2020) 583(7817):596602

an antibody derivative refers to, for example, but not by way of limitation, a polypeptide that comprises an amino acid sequence of an EphA2 or EphA4 polypeptide, a fragment of an EphA2 or EphA4 polypeptide, an antibody that specifically binds to an EphA2 or EphA4 polypeptide, or an antibody fragment that specifically binds to an EphA2 or EphA4 polypeptide, that has been altered by the introduction of amino acid residue substitutions, deletions or additions (i.e., mutations)

Corrao G, Lepore AR, Torchio P, Valenti M, Galatola G, DAmicis A, et al