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If antihistamines become routinely necessary, reconsider the protocol

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Apitherapy contains a number of chemical compounds which are natural agents with an approved range of activities and actions (11, 81)

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The first such therapies were available in the early 2000s, with bevacizumab approved in 2004 for colorectal cancer which was soon expanded to other types of cancer treatment including lung, glioblastoma multiforme, ovarian, renal, and metastatic breast cancer (240, 241)