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Early programmes, institutional studies, and preclinical model work examined how the compound class might influence receptor signalling, cellular adaptation, or tissue-level response patterns under controlled conditions

It added that DSHPs and DSIPs have grown from approximately $886 million in 2019 to nearly $2.7 billion in eligible expenditures in 2025

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Morgillo F, Della Corte CM, Fasano M, Ciardiello F

10.1016/j.ijbiomac.2024.134814 170 UlmerT

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