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Ozempic, Wegovy, compounded semaglutide, Mounjaro, Zepbound and compounded tirzepatide, the first three of which represent variations of semaglutide, and the last three represent variations in tirzepatide

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Data availability No primary research results, software or code have been included and no new data were generated or analysed as part of this review

Intriguingly, the steroid hormone precursor pregnenolone was recently identified as a putative endogenous negative allosteric modulator of CB1 receptors (Valle et al., 2014)