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Senolytic therapy preserves blood-brain barrier integrity and promotes microglia homeostasis in a tauopathy model

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10.1101/gad.279737.116 33 GasparriA

Despite significant individual differences, XpdTTD/TTD mice were found to run 1.37 0.54 km/day on average, compared to 9.37 1.1 km/day seen for wild-type mice, arguing they are indeed less mobile

As a result, daratumumab has shown a remarkable impact in treating lupus patients ( Mayo Clinic is currently conducting a Phase 2 clinical trial (NCT04868838) to assess the effectiveness and safety of Daratumumab in patients diagnosed with active LN

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