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However, tolerance does not affect BAC
Lessons for Peptide Drug Development AOD-9604 highlights how promising biochemical logic can falter in translation from bench to bedside
For context, the Phase 2 study (Jastreboff 2023, NEJM) reported about 17.5 percent mean weight reduction at 24 weeks on 12 mg
However, without concrete evidence, the theory was largely forgottenuntil now
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