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lipophilic lactone accumulates in muscle, causing mitochondrial dysfunction

5-Amino-1MQ blocks NNMT, the enzyme that drains nicotinamide away from the salvage pathway a close the drain approach

The GRAS determination was likely based on the compound's limited systemic absorption (when ingested), short plasma half-life, and lack of acute toxicity signals in the Phase 2b obesity trial

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Viola A, Munari F, Snchez-Rodrguez R, Scolaro T, Castegna A