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Its pharmacological precursor, ethyl pyruvate, has shown anti-inflammatory/anti-tissue injury effects in various animal models of disease, but failed in a multicenter clinical trial

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Methods Rat pups were treated with dimethylfumarate and the subcellular localization of Nrf2 was analyzed in the choroidal tissue by confocal imaging

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Both sulfur sources increased GSH and Cys content, particularly under high Cd stress, with FeS2 raising GSH and Cys levels by 3.3361.87% and 43.2971.94%, H2SO4 increased 15.6566.43% and 48.0274.58%, respectively (P0.05)