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Science 334 , 10971103 (2011)

In addition to viral replication, these proteins can trigger responses and induce cytotoxic and pro-inflammatory effects in neurons, dendritic cells (DCs), microglia, and macrophages, and astrocyte across the CNS, thereby contributing to the development of NeuroHIV [35,36,37]

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-Angelica lactone can give the chiral -amino ,-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the -carbon