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Humans only produce alpha-lipoic acid in small amounts

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Originally designed to inhibit ALK phosphorylation by interacting with the Y1230 residue and causing G1/S-phase cell cycle arrest and apoptosis [106], Crizotinib also has potent activity against c-MET with exon 14 alterations

While research into functional network connectivity has a potential to offer a better understanding of the neural origins of the complex cognitive, emotional, and physical symptoms of bipolar disorder, it requires consensus about the composition of functional networks, better control of confounding factors and more consistent, methodologically sound replications