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Genome-wide analysis of retroviral DNA integration

This ensures sustained homocysteine flux, which is critically converted to cysteine for GSH biosynthesis when the canonical cystine/glutamate antiporter (system xc-) is inhibited, a common trigger for ferroptosis (Cao et al., 2020)

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Vulnerabilities, such as glutamine or serine dependence, represent potential targets but are complicated by cancer cells ability to adapt via compensatory pathways

[DOI] [PubMed] [Google Scholar] 63.Nakai K., Yoneda K., Maeda R., Munehiro A., Fujita N., Yokoi I., Moriue J., Moriue T., Kosaka H., Kubota Y