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Further, owing to impaired mitochondrial autophagy, leakage of mtDNA and mitochondrial damage-associated molecular patterns (mDAMPs) in the cytoplasm activate an autocrine inflammatory response, which induces inflammatory response in neighboring hepatocytes and Kupffer cells [69]

Trindade, T., OBrien, P

While technically more cumbersome and thus more difficult to implement in most outpatient clinics, the difference in methodology has real clinical consequences