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For example, when hist amine is released during an allergic response, binding to the H1 receptor results in cell signaling that stimulates mucus secretion, increases vasodilation and vascular permeability and can lead to bronchoconstriction in allergy-induced asthma

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Jan 2021c;44(Suppl 1):S111-S124

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We predict that selective activation or inhibition of Nrf2 (as appropriate for different lung diseases), supplemented by drug therapy, will likely improve drug efficacy while reducing cellular tolerance to ferroptosis, and will become a major treatment approach for lung diseases in the future