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There is strong evidence linking elevated ROS levels to cancer progression (Glorieux et al., 2024)

Springerplus 3:668

Taken together, these findings confirm that, in addition to previously described effects of FGF2 on pluripotency markers expression, FGF2-mediated activation of PDH in 5% O 2 constitutes a key mechanism for generating the Ac-CoA pool required for histone acetylation

Most informative has been the magnetic resonance spectroscopy study performed in a large series of well-characterized GAD-positive patients with stiff-person syndrome (49)

What ties all three together is the starting point: comprehensive biomarker testing
