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FIGURE 2 On the other hand, in addition to its well-known functions, PGC1, a master regulator of mitochondrial biogenesis, positively regulates mitophagy by directly inducing the expression of transcription factor EB (TFEB) that mediates lysosomal biogenesis (Settembre et al., 2011)

Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B

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[DOI] [PMC free article] [PubMed] [Google Scholar] 39.Lombardo D., Calandra P., Barreca D., Magaz S., Kiselev M.A

Extracts. Journal of Materials and Environmental Science 7: 19881995