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However, it is important to note that curcumin has also been identified as a PAINS, exhibiting behaviors such as redox cycling, metal chelation, aggregation, and fluorescence interference that can artificially inflate its apparent bioactivity in vitro (Nelson et al., 2017)

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Calcium released in the cytoplasm causes cytoplasmic PKC to translocate to the plasma membrane while calcium that is released within the nucleus translocates nuclear PKC to the nuclear envelope.79 Also, there are separate pools of DAG produced by phospholipids localized within the cytoplasm or the nucleus.80 Furthermore, stimulusdependent production of DAG leads to selective translocation of specific PKC isoforms to the nucleus

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