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GSNO is metabolized by the NADH-dependent GSNOR, which thereby shifts the cellular equilibrium to disfavor protein SNOs, while Trxs and TrxRs denitrosylate proteins directly

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Immunoblot analysis showed FASN protein levels were substantially decreased in a dose-dependent manner with Chac1 overexpression (Figure 5L), indicating this effect by GSH depletion is intrinsic to hepatocytes

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H.PiccoM

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R., Wu, X

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& Wei, W

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