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4.2.2 ROS-independent NETosis and inflammasome-related amplification loops Besides the classic oxidative stress pathways, studies indicate that MSU crystals can also directly induce histone citrullination and NET formation through the TAK1/SYK/PAD4 axis or by directly activating the NF-B pathway, thereby bypassing the classic ROS burst (110, 112)

For a comprehensive summary of these trial results and Phase 3 updates, see our retatrutide clinical trials 2026 update

doi: 10.1007/s00259-012-2110-3 317 PfallerM