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Another chemoproteomics approach, led by Vividion Therapeutics identified a KEAP1 C151-reactive molecule which allosterically activates KEAP1, enhances the KEAP1:CUL3 interaction, and promotes NRF2 degradation [88]
On the other hand, for 2 weeks, the (+) ALA group took two softgels per day of ALA, GLA, B vitamins, vitamin E, and selenium (corresponding to ALA 600 mg/day)
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doi: 10.1016/j.celrep.2017.07.054 15 HeZZhangS
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