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Primary antibodies were purchased from the following companies: glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (Beyotime, Shanghai, China), heme oxygenase-1 (HO-1), solute carrier family 7 member 11 (SLC7A11) and Hypoxia-inducible factor-1 (HIF-1) (Proteintech, Wuhan, China), NADPH-quinone oxidoreductase1 (NQO-1) (HuaBio, Hangzhou, China), glutathione peroxidase4 (GPX4), acyl-CoA synthetase long-chain family member4 (ACSL4) and Sirtuin4 (SIRT4) (abclonal, Wuhan, China), lymphocyte antigen 6 complex locus G6D (Ly6G) and myeloperoxidase (MPO) (Abcam, Shanghai, China), cluster of differentiation molecule 11b (CD11b) (Boster, Wuhan, China), 4-hydroxynoneral (4-HNE)(RD systems, Shanghai, China)

7, 693698.10.1038/89068 33 DurandE.Al Haj ZenA.AddadF.BrasseletC.CaligiuriG.VinchonF.LemarchandP.DesnosM.BrunevalP.LafontA

All participants provided written, informed consent

doi: 10.1111/j.1471-4159.2009.06550.x

doi: 10.1021/acs.molpharmaceut.5c00056 165 MakadiaH

Aesthetic results: Composite dental filling materials are color-matched to your existing tooth shade, making them virtually invisible