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No dose-escalation or maximum tolerated dose studies have been conducted, limiting understanding of safety at higher doses

doi: 10.1002/mabi.200900129

In yeast, Ohsumis and Klionskys laboratories first identified that ATG32 acts as the mitophagy-specific receptor, which directly interacts with the selective autophagy adaptor ATG8 via an ATG8-interacting motif (AIM) and ATG11 to form the nascent autophagosome (Kanki et al., 2009