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MC4R-expressing neurons in this region project to brainstem autonomic centers and interface with mesolimbic dopaminergic pathways the reward and motivation circuitry that underpins sexual desire

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9,12,13 Prodromal signs and symptoms of HL include discomfort, burning, itching, tingling, localized warmth, and erythema of the affected epithelial tissue, occurring 6 to 24 hours before lesion development