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The M1/M2 classification based on cytokine-induced polarization in vitro is a simplified model that does not reflect the macrophage heterogeneity in vivo

Randomized pilot study

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The major reason as to why maintaining a healthy cellular glutathione (GSH) level is so critical for the immune system is related to the fact that lymphocytes perform their bacterial, viral and cancer cell killing functions by generating large amounts of ROS including superoxide and hydrogen peroxide