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Four APK proteins exist in Arabidopsis, APK1, 2, and 4 locate in plastids whereas APK3 is in the cytosol (Mugford et al., 2009)

The task of disrupting TCF/-catenin interaction specifically, however, is a difficult one since -catenin interacts with TCF and other binding partners such as APC, Axin and E-cadherin via the same or overlapping interface (Barker and Clevers, 2006)

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Harm-reduction approaches to alcohol treatment encompass an array of practices and policies that aim to minimize the negative physical, social, and/or functional impacts of alcohol use, and they typically embrace the notion that there are multiple pathways to recovery from a SUD