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Ammonia accumulation in CD8+ T cells triggers PD-1 upregulation via ROS/NF-B (189, 190), while scavenging ammonia augments PD-1 blockade response in vivo ( 191)

doi: 10.3389/fmicb.2025.1677102 Received 31 July 2025 Accepted 31 October 2025 Published 21 November 2025 Volume 16 - 2025 Edited by Gregg Pettis, Louisiana State University, United States Reviewed by Jong Hyun Ham, Louisiana State University, United States Cong Zhang, Qingdao Agricultural University, China Updates Copyright 2025 Shigeta, Shiraishi, Schroll, Lauer, Keppler, Sakai and Yurimoto

Replicatively senescent human fibroblasts reveal a distinct intracellular metabolic profile with alterations in NAD+ and nicotinamide metabolism

All human evidence consists of case reports and anecdotal experience

Bone Health The vitamin D2 in button mushrooms directly supports calcium absorption and bone mineralization