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PMID: 7569285

doi: 10.1073/pnas.91.2.584 82 MisraR

According to the exploration results of the T1D patients or models, the following bacteria were mainly increased in abundance: Bifidobacterium longum (166, 167), Eubacterium rectale (168), Bacteroides uniformis (169), Lachnospira spp., Intestinimonas spp., Micrococcales spp (170)., Actinomyces spp (171)., Bacteroides spp (172)., Prevotella spp (168)., Ruminococcus spp (173)., and Veillonella spp (174)., whereas the bacterium with decreased abundance mainly includes butyrate-producing bacterium, lactic acid-producing bacterium, and mucin-degrading bacterium, such as Lactococcus , Lactobacillus ( 173), Streptococcus (174), Bifidobacterium , Proteobacteria (172), Subdoligranulum , Roseburia , Eubacterium , Anaerostipes (175), FP (176, 177), Clostridium clusters IV (178, 179), and XIVa (180, 181)

Intestinal epithelial cells establish a continuous monolayer through TJs, which comprise transmembrane proteins (e.g., occludin), claudin family proteins (e.g., claudin-1), and cytoplasmic scaffolding proteins (e.g., ZO-1, ZO-2, ZO-3).[13]

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Ischaemia can be global or focal and acute or chronic