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Oncogene (2021) 40(49):666679

S methylation Thiol methylation is important in the metabolism of many sulfhydryl drugs

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Ferroptosis in spinal cord ischemia-reperfusion injury Spinal ischemia-reperfusion injury (SCIRI) is a common complication after thoracic and abdominal aortic surgery, and can also be caused by spinal trauma and spinal degeneration, leading to severe sensory and motor dysfunction

When cells are exposed to oxidative stress, electrophiles or chemopreventive agents, Nrf2 escapes Keap1-mediated repression, and translocates and accumulates in the nucleus, thus activating ARE-dependent gene expression to maintain cellular redox homeostasis.174,175 Several mechanisms have been proposed to explain the repressive effect of Keap1 on Nrf2, namely: i) Keap1 is a thiol-rich sensor protein, which is an adaptor protein for Cullin 3-dependent ubiquitination and degradation of Nrf2;176 electrophile modification of the Keap1 central linker domain would switch ubiquitination from Nrf2 to Keap1, leading to Nrf2 activation