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Their influence on neuronal communication and brain homeostasis is largely exerted via gliotransmitters such as GABA, glutamate, D -serine, lactate, and ATP/adenosine, in addition to neurotrophic factors like proBDNF and BDNF

EAAC1 gene expression is promoted by nuclear factor erythroid 2-related factor 2 (Nrf2) [64], regulatory factor X1 (RFX1) [65], and all-trans-retinoic acid (ATRA) [66], while miR-96-5p, which is one of the microRNAs (miRNAs), has a target sequence in the 3-UTR of EAAC1 and suppresses the protein expression of EAAC1 posttranslationally, leading to decreased GSH levels in the brain [67,68] (Figure 3)

These metabolic processes are vital for sustaining the integrity of the nervous system, as the energy produced is critical for the functioning of nerve cells

EGCG has antioxidant and iron-chelating properties

Pruimboom and Muskiet, 2018

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