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Mokhtari et al., 2017)

The released Mn 2+ can in turn mediate Fenton-like reactions by catalyzing the generation of highly active OH from H 2 O 2 (32) to induce high oxidative stress in tumor cells and the production of proinflammatory factors, such as TNF- (5255)

These in-organ changes in energy metabolism are also reflected in the plasma metabolome after ischemic AKI, which is characterized by the depletion of numerous amino acids and energy substrates 6

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Gold KA, Lee JJ, Rice DC , Tse W, Stewart D, Wistuba I, Herbst RS, Swisher SG, Lippman SM, Kim ES