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The ability to incorporate systemic modifiers such as diabetes, obesity, or aging into these models further enhances their relevance, allowing researchers to explore how systemic inflammation, metabolic dysregulation, or immunosenescence influences disease susceptibility and the capacity for repair [71, 72, 73, 74, 75]

The effectivity of BBB-specific cellular internalization and permeability can be increased by the combination of different targeting ligands on the surface of nanocarriers

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Fry AM, ORegan L, Sabir SR, Bayliss R (2012) Cell cycle regulation by the NEK family of protein kinases

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