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6-Phosphogluconolactonase then hydrolyzes the lactone to 6-phosphogluconate via a proton-relay mechanism involving conserved histidine and aspartate residues

Wade, D.S

observed in human keratinocytes that IR-induced GSH depletion occurred despite unchanged expression of SLC7A11 and apparent upregulation of Glutamate-Cysteine Ligase, the rate-limiting enzyme responsible for GSH synthesis, suggesting the role of another GSH regulator [38]

Hepatotoxicity, mainly of paracetamol, is attributed to its conversion into a highly reactive metabolite called N-Acetyl-p-benzoquinone imine (NAPQI) by microsomal enzymes from the P450 family

ostreatus (Pb) counteract high metal concentrations by the action of antioxidant enzymes (e.g., superoxide dismutase

10.1172/jci142239 63 GaryW.ClaudineM