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Whereas current clinical guidelines emphasize low values of total testosterone concentrations as a requirement for making the diagnosis of testosterone deficiency, it is acknowledged that there is no absolute testosterone concentration that accurately and reliably separates men who do and who do not have testosterone deficiency [37, 38] We believe the results of the present study support the possibility that a set of biomarkers can be used to assist with the identification of these men, including PSA, LDH, estradiol, creatinine, and possibly BAP