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It is a limitation in the sense that it is not clear which of these effects is the most important to optimize for health benefitsalthough by optimizing induction of expression of Glo1, we arrived at the combination of tRES-HESPa supplement that had profound health benefit in a clinical trial [43]

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Pharmacokinetic profiles for the compound place its plasma half-life in the neighborhood of 45 minutes after parenteral administration in animal models, which informs typical dosing intervals in published experiments

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