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Non-receptor-mediated actions are due to amphipathic properties (of both lipo- and hydrophilic structure) that allows melatonin to freely cross the cell and nuclear membranes

Mesenchymal stem cells reverse EMT process through blocking the activation of NF-B and hedgehog pathways in LPS-induced acute lung injury

Blood 118(21):421-22, 2011

Franz AP, Bolat GU, Bolat H, Matijasevich A, Santos IS, Silveira RC, et al

Although these findings do not exclude Prx-independent H 2 O 2 signaling mechanisms, they clearly show that Prxs act as sensitive and common transducers of H 2 O 2 -derived oxidizing equivalents in redox signaling [18,19]

& Simpson, E