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Taken together, these findings demonstrate that Hb, particularly astrocytic Hb in the hippocampus and both astrocytic and neuronal Hb in the SNpc, is essential for the therapeutic effects of KDS12025, underscoring its pivotal role in mitigating oxidative stress and neurodegeneration in AD and PD models

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Bahrambeigi, V, Lee, JJ, Branchi, V, Rajapakshe, K, Xu, Z, Kui, N, Henry, JT, Kun, W, Stephens, BM, Dhebat, S, Hurd, MW, Sun, R, Yang, P, Ruppin, E, Wang, W, Kopetz, S , Maitra, A, Guerrero, PA