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COMT is an enzyme that breaks down levodopa (49)

This disruption can lead to the manifestation of autistic symptoms ( 3 Research on the association between GABA and ASD 3.1 The relationship between GABAergic interneurons abnormalities and ASD In the mammalian brain, inhibitory GABAergic neurons are primarily interneurons, which include parvalbumin (PV)-expressing interneurons, somatostatin (SST)-expressing interneurons, vasoactive intestinal peptide (VIP)-expressing interneurons, and interneurons expressing the ionotropic serotonin receptor (5HT3a) ( Figure 1 )

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Combined with maintaining organ resilience, immune responses remain controlled

This finding is also supported by several genetic variations seen in ASD patients related to the transmethylation/transsulfuration pathway, where glutathione is one of the byproducts (1618)

These effects were specifically attributed to benfotiamine, considering that neither fursultiamine nor high doses of thiamine produced a similar result