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In M1 macrophages, aerobic glycolysis induction depends entirely on redox-sensitive transcription factor HIF1 activated by the NF-B pathway during inflammation

Answer 2

Consequently, any factor inhibiting SLC7A11 function or downregulating its expression leads to intracellular GSH depletion, thereby depriving GPX4 of its essential substrate and ultimately triggering irreversible ferroptosis

doi: 10.3390/IJMS25136945 94

Exercise and hydration enhance circulation and nutrient delivery to skin, while stress management lowers cortisol-related collagen degradation

[DOI] [PubMed] [Google Scholar] Casas AI, Dao VT, Daiber A, Maghzal GJ, Di Lisa F, Kaludercic N, Leach S, Cuadrado A, Jaquet V, Seredenina T, Krause KH, Lpez MG, Stocker R, Ghezzi P, Schmidt HH