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Skeletal muscle acidosis and dysregulated protons have also been found in patients during or after exercise (401404)

This led to significant interest in understanding the mechanisms and develop appropriate treatment strategies

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doi: 10.1104/pp.106.078246

Chandan Sen and Lester Packer also played a key role in highlighting the potential job that free radicals play in modulating cell signaling processes (353) and helped initiate the interest in redox-signaling that continues to the current day