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Mutation of a transcription factor, TFCP2L3, causes progressive autosomal dominant hearing loss, DFNA28
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Moreover, ER stress induced by NS5A and core HCV proteins causes calcium release from the ER into the cytoplasm
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On the one hand, a certain physiological level of ROS plays an important regulatory role, participating as specific signaling molecules in the regulation of metabolic processes, gene expression, and the functioning of the immune, endocrine and other physiological systems [4]
