glutathione conjugate processing Conjugation The Role of Glutathione Metabolism

Other conditions known to influence expression of GCLC at the transcriptional level include treatments with antioxidants such as butylated hydroxyanisole [74,75], 5,10-dihydroindeno [1,2-b]indole and tert-butyl hydroquinone (TBH) [44,76,77], inducers of Phase II detoxifying enzymes such as -naphthoflavone (-NF) [78], formation of Michael reaction acceptors (containing an electrophilic electron-deficient center that is susceptible to nucleophilic attack) by treatment with diethyl maleate (DEM) to produce GSH conjugates [75], heat shock [79], zinc [80], melatonin [81], curcumin [82], and lipid peroxidation products such as 4-hydroxynonenal (4-HNE), 15-deoxy- 12,14 -prostaglandin J 2 (15d-PGJ 2 ) [8386], trivalent arsenite (As 3+ ) [87], and ajoene, a major compound in garlic extracts [88]

These effects could result in gray hair and other noticeable symptoms

NEB) with NEBNext Poly(A) mRNA Magnetic Isolation Module (E7490

Nat Immunol 25 , 13321343 (2024)

A.HuangY.BieZ.AhmedW.ReiterR

doi: 10.1016/0378-5955(87)90195-X