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In 1951 Conley and Krevans from the Johns Hopkins Hospital challenged the practice, raising the possibility that the neurological manifestations in some new pernicious anemia patients may be linked to previously prescribed high oral doses of folic acid (2028 mg/d) (12)

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SLC29A1 and SLC29A2 are human nicotinamide cell membrane transporters

Conversely, individuals with minimal subcutaneous fat should use shorter needles to avoid intramuscular delivery

A separate B12 supplement is usually necessary

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