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Contrarily, controlling of angiogenesis is along with an increased angiogenesis to promote healing, 73 an increased expression of vascular endothelial growth factor (VEGF) and subsequent pathways, 2 , 96 - 101 and as study of Kang et al., 2 documented, BPC 157 fully counteracted tumor cachexia, and prolonged survival, counteracted increase of the pro-cachectic and pro-inflammatory cytokines, and related molecular pathways effects

This observation has spurred extensive investigation into its physiological roles

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Semin Neurol 10:4245 Lojo N, Rasic Z, Zenko Sever A et al (2016) Effects of diclofenac, l-NAME, l-Arginine, and pentadecapeptide BPC 157 on gastrointestinal, liver, and brain lesions, failed anastomosis, and intestinal adaptation deterioration in 24 hour-short-bowel rats