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These findings suggest direct pro/anti-inflammatory actions of IGF-1 which regulates neuroinflammation and is involved in neuroprotection by maintaining the cerebromicroenvirontment, increasing the capillary density and microglial activation in neuroinflammation by TLR4 signaling (Fig

27 Opioids are implicated in overdose deaths more than any other drug class, ending more lives than guns, breast cancer, or car accidents

Health 30, 100646

Tautenhahn R, Cho K, Uritboonthai W, et al

This has contributed to several unfortunate consequences including (i) the difficulty for mainstream science to accept that ERW has biological effects, (ii) the persistence and proliferation of debunked and pseudoscientific claims about ERW, (iii) inadequate scientific research on ERW, (iv) health-conscious consumers being taken advantage of when purchasing suboptimal devices, and (v) ignoring several safety concerns or even promoting them as benefits

3c, supplementary Table S5)