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reported that Shaoyao-Gancao Decoction (SGD), commonly used to treat multiple gynecological disorders such as dysmenorrhea, adenomyosis, and PCOS, modulated gut microbiota composition, and alleviated chronic low-grade inflammation by downregulating cytokines including IL-18, IL-1, IL-6, and TNF- in both serum and ovarian mRNA expression in PCOS rats (238)

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Similarly, lower serum concentrations of RvD1, together with increased connective tissue growth factor levels, have been correlated with RA onset and progression [47]