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Joosten E, van den Berg A, Riezler R, et al

doi: 10.1016/j.tem.2022.05.003 34
Mitochondria were treated with pyruvate/malate/FCCP followed sequentially with rotenone, succinate, antimycin A, and N,N,N,N-Tetramethyl-p-phenylenediamine (TMPD)/ascorbic acid (n = 5)
healthy breast tissues were subjected to Gene Ontology (GO) (cellular component, molecular function and biological process) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses (log FC 1
An inadequate selenium supply impairs the synthesis of the mitochondrial envelope of sperm, which affects sperm motility and may lead to infertility (Wang et al., 2021)

These alterations result in a significantly extended half-lifeup to 120 times longer than native IGF-1due to reduced binding affinity to insulin-like growth factor-binding proteins (IGFBPs)
