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To investigate this further and gain a broader understanding of how ECM components shape the MC phenotype, we performed bulk RNA sequencing (RNAseq) on iMCs cultured on stiff substrates coated with COL IV, COL I, or FN (Figs

Nat Genet 20:113114 [DOI] [PubMed] [Google Scholar] Yeo GS, Farooqi IS, Aminian S, Halsall DJ, Stanhope RG, O'Rahilly S 1998 A frameshift mutation in MC4R associated with dominantly inherited human obesity

In: Gospodarowicz MK, OSullivan B, Sobin LH, eds

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NICE guidelines for weight management emphasise evidence-based interventions including dietary modification, increased physical activity, behavioural therapy, and in appropriate cases, pharmacological treatments (such as orlistat or semaglutide) or bariatric surgery
